Talking with your
doctor is the first step.

Marnina
HIV Activist
Switched to DOVATO

You may be able to stay undetectable* with fewer medicines.

Talking to your doctor about DOVATO

Ask your doctor if 2 medicines in 1 pill is right for you.

Whether you’re already on treatment or new to treatment, you can use this as a guide to chat with your doctor about DOVATO.

Undetectable and already on HIV treatment?

Here are a few questions to ask your doctor.

Could fewer medicines^† be a good option for me to continue controlling my HIV? What are the benefits and risks?
How many medicines does my current treatment have?
Can DOVATO keep me undetectable?*
How will taking DOVATO fit into my life and daily schedule?

New to HIV treatment?

Here are a few questions to ask your doctor.

Could DOVATO be a good option for me to control my HIV? What are the benefits and risks?
How many medicines are in my different treatment options?
Can I reach and then stay undetectable^* with DOVATO?
How will taking DOVATO fit into my life and daily schedule?

detect this:
talking to your doctor starts with a C.H.A.T.

Communicate about your life and schedule

Hear about treatment options

Ask questions

Talk about your health goals

Looking for more resources and support for DOVATO?

Start here

Think about these things:

Your schedule
HIV medications have to be taken as directed by your doctor to reach and keep HIV undetectable.* Do you work long hours? Eat at different times each day? Telling your doctor about your routine will help them find a treatment that will work for you.

Types of treatment
Today, many single-tablet HIV treatments have at least 3 different medicines combined into 1 pill. DOVATO delivers powerful results^‡ with just 2 medicines in 1 pill. It’s proven as effective as an HIV treatment with 3 or 4 medicines. That means fewer medicines^† in your body, today and tomorrow, while taking DOVATO.
Results may vary.

Your other medicines
You may be taking additional medicines. Since some medicines don’t work well when taken together, it’s important to let your doctor know about any prescription or over-the-counter medicines or supplements you are taking. That way they can prescribe a treatment that will work for you—and works with your other medicines.

Your HIV health goals
Do you know how many medicines are in your current HIV treatment? Could fewer medicines work for you? Ask your doctor if taking fewer medicines^† with DOVATO could be part of a healthy future.

* Undetectable means the amount of HIV in the blood is below the level that can be measured by a lab test.
As compared with 3- or 4-drug regimens.
Based on data from the GEMINI 1 & 2 studies (patients new to treatment) and TANGO study (patients replacing their current HIV treatment). DOVATO was compared with a regimen containing either 3 or 4 medicines, measuring either the percentage of patients with an undetectable viral load (<50 copies/mL) or the percentage of patients without an undetectable viral load (≥50 copies/mL).

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What is DOVATO?

DOVATO is a complete prescription regimen to treat HIV-1 in adults who have not received HIV-1 medicines in the past or to replace their current HIV-1 medicines when their doctor determines they meet certain requirements.

IMPORTANT SAFETY INFORMATION

LEARN WHY PATIENTS SWITCHED

What is the most important information I should know about DOVATO?

If you have both HIV-1 infection and Hepatitis B virus (HBV) infection, DOVATO can cause serious side effects, including:

Resistant HBV. Your healthcare provider will test you for HBV infection before you start treatment with DOVATO. If you have HIV-1 and hepatitis B, the HBV can change (mutate) during your treatment with DOVATO and become harder to treat (resistant). It is not known if DOVATO is safe and effective in people who have HIV-1 and HBV infection.

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What is DOVATO?

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about DOVATO?

If you have both HIV-1 infection and Hepatitis B virus (HBV) infection, DOVATO can cause serious side effects, including:

Resistant HBV. Your healthcare provider will test you for HBV infection before you start treatment with DOVATO. If you have HIV-1 and hepatitis B, the HBV can change (mutate) during your treatment with DOVATO and become harder to treat (resistant). It is not known if DOVATO is safe and effective in people who have HIV-1 and HBV infection.
Worsening of HBV infection. If you have HBV infection and take DOVATO, your HBV may get worse (flare-up) if you stop taking DOVATO. A “flare-up” is when your HBV infection suddenly returns in a worse way than before.
- Do not run out of DOVATO. Refill your prescription or talk to your healthcare provider before your DOVATO is all gone.
- Do not stop DOVATO without first talking to your healthcare provider.
- If you stop taking DOVATO, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your liver function and monitor your HBV infection. It may be necessary to give you a medicine to treat hepatitis B. Tell your healthcare provider about any new or unusual symptoms you may have after you stop taking DOVATO.

For more information about side effects, see “What are the possible side effects of DOVATO?”

Who should not take DOVATO?

Do not take DOVATO if you:
- have ever had an allergic reaction to a medicine that contains dolutegravir or lamivudine.
- take dofetilide. Taking DOVATO and dofetilide can cause side effects that may be serious or life-threatening.

What are other possible side effects of DOVATO?

DOVATO can cause serious side effects, including:

See "What is the most important information I should know about DOVATO?"
Allergic reactions. Call your healthcare provider right away if you develop a rash with DOVATO. Stop taking DOVATO and get medical help right away if you develop a rash with any of the following signs or symptoms:
- fever
- generally ill feeling
- tiredness
- muscle or joint aches
- blisters or sores in mouth
- blisters or peeling of the skin
- redness or swelling of the eyes
- swelling of the mouth, face, lips, or tongue
- problems breathing
Liver problems. People with a history of hepatitis B or C virus may have an increased risk of developing new or worsening changes in certain liver tests during treatment with DOVATO. Liver problems, including liver failure, have also happened in people without a history of liver disease or other risk factors. Your healthcare provider may do blood tests to check your liver.
- Tell your healthcare provider right away if you get any of the following signs or symptoms of liver problems:
- your skin or the white part of your eyes turns yellow (jaundice)
- dark or “tea-colored” urine
- light-colored stools (bowel movements)
- nausea or vomiting
- loss of appetite
- pain, aching, or tenderness on the right side of your stomach area
Too much lactic acid in your blood (lactic acidosis). Too much lactic acid is a serious medical emergency that can lead to death.
- Tell your healthcare provider right away if you get any of the following symptoms that could be signs of lactic acidosis:
- feel very weak or tired
- unusual (not normal) muscle pain
- trouble breathing
- stomach pain with nausea and vomiting
- feel cold, especially in your arms and legs
- feel dizzy or light-headed
- have a fast or irregular heartbeat
Lactic acidosis can also lead to severe liver problems, which can lead to death. Your liver may become large (hepatomegaly) and you may develop fat in your liver (steatosis). Tell your healthcare provider right away if you get any of the signs or symptoms of liver problems which are listed above under “Liver problems.”
You may be more likely to get lactic acidosis or severe liver problems if you are female or very overweight (obese).
Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV-1 medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your healthcare provider right away if you start having new symptoms after you start taking DOVATO.
The most common side effects of DOVATO include:
- headache
- nausea
- diarrhea
- trouble sleeping
- tiredness
- anxiety

These are not all the possible side effects of DOVATO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my healthcare provider before taking DOVATO?

Before you take DOVATO, tell your healthcare provider about all of your medical conditions, including if you:

have or have had liver problems, including hepatitis B or C infection.
have kidney problems.
are pregnant or plan to become pregnant. One of the medicines in DOVATO (dolutegravir) may harm your unborn baby.
- Your healthcare provider may prescribe a different medicine than DOVATO if you are planning to become pregnant or if pregnancy is confirmed during the first 12 weeks of pregnancy.
- If you can become pregnant, your healthcare provider may perform a pregnancy test before you start treatment with DOVATO.
- If you can become pregnant, you and your healthcare provider should talk about the use of effective birth control (contraception) during treatment with DOVATO.
- Tell your healthcare provider right away if you are planning to become pregnant, you become pregnant, or think you may be pregnant during treatment with DOVATO.

are breastfeeding or plan to breastfeed. Do not breastfeed if you take DOVATO.
- You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.
- One of the medicines in DOVATO (lamivudine) passes into your breast milk.
- Talk with your healthcare provider about the best way to feed your baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Some medicines interact with DOVATO. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

You can ask your healthcare provider or pharmacist for a list of medicines that interact with DOVATO.
Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take DOVATO with other medicines.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please read the Patient Information for DOVATO and discuss it with your healthcare provider.

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